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Biological versus mechanical prostheses for aortic valve replacement

May 17, 2021

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Rodríguez-Caulo, Emiliano A., et al., Journal of Thoracic and Cardiovascular Surgery (2021) DOI:10.1016/j.jtcvs.2021.01.118

Aim

Evaluate long-term survival and major adverse events in patients aged 50 to 65 years with a primary isolated AVR, with a bioprosthesis or mechanical valve, because of severe AS

Methods

  • National observational study with all consecutive patients aged 50-65 who underwent AVR because of severe isolated AS between 2000 and 2018 in 27 hospitals in Spain
  • In total, 5215 patients were included in the study (21% were bioprostheses)
  • Among bioprostheses, 46.8% were Carpentier-Edwards, 19.4% Mitroflow, 4.2% Mosaic and 4.1% Trifecta
  • 2:1 propensity matching analysis (1822 Mech and 911 Bio) with a mean follow-up of 8.1 years

Results

Conclusions

  • Bioprostheses seem a reasonable choice for patients aged 50 to 65 years in Spain, particularly for those older than 55 years, because of the long-term survival and the lower-risk related, especially, to major bleeding compared with mechanical prostheses
  • However, the higher risk of reoperation with bioprostheses should be considered and discussed with the patient to make the best-informed decision

Key talking points

Are these outcomes aligned with guideline recommendations? – Current ESC/EACTS guidelines consider mechanical and bioprosthetic valves as reasonable in patients aged 60 to 65 years, whereas AHA/ACC guidelines consider both reasonable in 50 to 65 y.o. patients. Therefore, findings from this national observational study with patients that underwent isolated AVR seem to be more aligned with the latest American guidelines.

Why did the risk of reintervention decrease in patients who underwent Bio AVR between 2009 and 2018? The authors point to improved outcomes after AVR for both mech and bio prostheses after 2009. In the unadjusted cohort, there was a significant decrease in stroke, major bleeding and reintervention. In the bio group, the rate of reoperation because of SVD diminished from 7.6% to 4% after 2009, which is related to the durability of bioprostheses. Improvements in the bio group may be linked to the incorporation of newer anticalcification properties.

What is the mortality risk associated with prosthesis reintervention? – Today, mortality risk associated with prosthesis reintervention has been minimized, and most recent bioprostheses allow for “valve-in-valve” procedures for patients at high surgical risk.

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