Late clinical and echocardiographic results with the Magna Ease pericardial aortic bioprosthesis
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Late clinical and echocardiographic results with the Magna Ease pericardial aortic bioprosthesis

Anselmi A, D’alessandro G, Tomasi J, Aymami […]

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Late clinical and echocardiographic results with the Magna Ease pericardial aortic bioprosthesis

Anselmi A, D’alessandro G, Tomasi J, Aymami M, Mancini J, Corbineau H, Flécher E, Verhoye J-P.

Presented at 36th European Association for Cardio-Thoracic Surgery Annual Meeting, 2022. 

Key points:

  • The Carpentier-Edwards PERIMOUNT Magna Ease valve had a low rate of structural valve deterioration (SVD) throughout over a decade of follow-up.
  • Haemodynamic outcomes were stable over time.

Background information

  • The PERIMOUNT Magna Ease valve has been available for use in aortic valve replacement surgery since the late 2000s.1

  • Several studies have assessed the early and medium-term performance of the PERIMOUNT Magna Ease valve, but only limited data on long-term outcomes are available.2

  • However, the number of relatively young patients receiving biological valves is increasing, thus creating a need for long-term data on bioprostheses.


  • To evaluate the long-term durability and clinical performance of the PERIMOUNT Magna Ease valve.

Type of study

  • A single-centre study with systematic follow-up.


  • Endpoints included overall survival, echocardiographic results, and freedom from SVD, reinterventions for SVD, or valve-related death.


  • The study included all comers who underwent surgical aortic valve replacement with the PERIMOUNT Magna Ease valve between 2008 and 2014.
  • In-hospital data were collected prospectively.
  • Patients were subject to systematic follow-up, including echocardiographic examinations.
  • Valve-related adverse events were defined as SVD, non-structural valve dysfunction, infectious prosthetic endocarditis or prosthesis-patient mismatch.



  • The study included 1,017 patients with a mean age of 4 years ± 9.5; 59.6% of patients had calcified aortic stenosis and 11.9% had bicuspid morphology.
  • The majority of procedures were elective (95.1% vs 4.9% non-elective procedures) and 34.1% of patients underwent concomitant procedures.
  • A total of 975 patients entered follow-up (median follow-up: 8 years; follow-up completeness: 100%), 57.9% (n=565) of whom survived.
  • The median follow-up time among survivors was 9 years (95% confidence interval 0.2–13.4).

Table 1. SVD and SVD-related reinterventions (Kaplan–Meier analysis).


  • Overall survival was 8% after 10 years and 43.2% after 12 years.
  • Twenty valve-related deaths occurred during follow-up.
  • Freedom from valve-related death was 8% after 10 years and 96.9% after 12 years.


  • The number of SVD events was 28 after 6.9 ± 3.3 years of follow-up (Table 1).
  • The number of valve-related reinterventions was 31 after 8 ± 2.9 years.

Haemodynamics performance

  • Haemodynamic performance was stable from discharge to last available follow-up (Table 2).

Table 2. Haemodynamics function at discharge and last follow-up.


The PERIMOUNT Magna Ease valve showed optimal and maintained haemodynamic performance with good durability and limited other valve-related adverse events for up to 12 years after implantation. There is a need for studies with longer follow-up periods, because many patients receiving bioprostheses have a life expectancy longer than 12 years.


  1. Edwards Edwards Lifesciences receives FDA approval for new heart valve. Press release, 08 May 2009. Available at: [Accessed October 2020].
  3. Mayr B, Burri M, Vitanova K et al. Serial echocardiographic evaluation of the Perimount Magna Ease J Thorac Dis. 2021; 13: 4104-13.

This document is a summary of the Anselmi A et al. presentation, as presented at the EACTS congress, and covers key information including aim, type of study, methods, results, limitations and conclusions.

The full publication is available at:


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