{"id":7345,"date":"2022-12-08T11:13:55","date_gmt":"2022-12-08T11:13:55","guid":{"rendered":"https:\/\/edwardseducation.com\/edwardsmasters\/?p=7345"},"modified":"2023-04-24T12:24:51","modified_gmt":"2023-04-24T12:24:51","slug":"standardized-subannular-repair-in-type-iiib-mitral-regurgitation-1-year-results-from-reform-mr-registry","status":"publish","type":"post","link":"https:\/\/edwardseducation.com\/edwardsmasters\/standardized-subannular-repair-in-type-iiib-mitral-regurgitation-1-year-results-from-reform-mr-registry\/","title":{"rendered":"Standardized subannular repair in type IIIb mitral regurgitation: 1-year results from REFORM-MR Registry"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"7345\" class=\"elementor elementor-7345\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-63034de elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"63034de\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b117ae5\" data-id=\"b117ae5\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b5cca94 elementor-widget elementor-widget-text-editor\" data-id=\"b5cca94\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Girdauskas E, Pausch J, Eden M, Krane M, Borger M, Walther T, Kuntze T and Falk V.<\/p><p><em>Presented at 36<\/em><em>th<\/em><em>\u00a0<\/em><em>European Association for Cardio-Thoracic Surgery Annual Meeting, 2022.<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-14b448c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"14b448c\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-004bdd5\" data-id=\"004bdd5\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8d54873 elementor-widget elementor-widget-heading\" data-id=\"8d54873\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Key points:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c21ce4f elementor-widget elementor-widget-text-editor\" data-id=\"c21ce4f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul>\n<li>Annuloplasty combined with papillary muscle repositioning to treat type IIIb mitral regurgitation (MR) had acceptable perioperative and 1-year efficacy and safety outcomes.<\/li>\n<\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c6d0ee4 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c6d0ee4\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-fba092c\" data-id=\"fba092c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-3fa57a0 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3fa57a0\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-e37ef44\" data-id=\"e37ef44\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1ba7b63 elementor-widget elementor-widget-heading\" data-id=\"1ba7b63\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Background information<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b09caf5 elementor-widget elementor-widget-text-editor\" data-id=\"b09caf5\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Treating type IIIb MR with annuloplasty alone is associated with a high recurrence rate.<\/li><li>Combining annuloplasty with subannular repair by papillary muscle repositioning may increase the stability of mitral valve repair in this patient population.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f2d92dc elementor-widget elementor-widget-heading\" data-id=\"f2d92dc\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Aims<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cb11537 elementor-widget elementor-widget-text-editor\" data-id=\"cb11537\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>To evaluate the safety and efficacy of standardised subannular repair.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-31df1c1 elementor-widget elementor-widget-heading\" data-id=\"31df1c1\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Type of study<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-90fa600 elementor-widget elementor-widget-text-editor\" data-id=\"90fa600\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>A prospective, single-arm, multicentre registry study.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-60f2cf9 elementor-widget elementor-widget-heading\" data-id=\"60f2cf9\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Endpoints<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7639f97 elementor-widget elementor-widget-text-editor\" data-id=\"7639f97\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>The primary endpoint was freedom from MR &gt;2+ after 2 years.<sup>1<\/sup><\/li><li>Secondary endpoints included survival, major adverse cardiac and cerebrovascular events and reinterventions.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-875172f elementor-widget elementor-widget-heading\" data-id=\"875172f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Methods<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-483910a elementor-widget elementor-widget-text-editor\" data-id=\"483910a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>The study included patients with secondary MR, left ventricular ejection fraction (LVEF) \u226450%, left ventricular end-diastolic diameter (LVEDD) \u226555 mm and tenting of the proximal or anterior mitral leaflets &gt;10 mm.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-06fae8a\" data-id=\"06fae8a\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5bf2411 elementor-widget elementor-widget-text-editor\" data-id=\"5bf2411\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Patients underwent annuloplasty (with Carpentier- McCarthy-Adams IMR ETlogix) together with bilateral papillary muscle repositioning.<\/li><\/ul><ul><li>Endpoint assessment was performed in echocardiography and magnetic resonance imaging CoreLabs.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9617afb elementor-widget elementor-widget-heading\" data-id=\"9617afb\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Results<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-abbe715 elementor-widget elementor-widget-text-editor\" data-id=\"abbe715\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Patients<\/b><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-eee41bb elementor-widget elementor-widget-text-editor\" data-id=\"eee41bb\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>The study included 94 patients from six centres (Table 1).<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-33eac66 elementor-widget elementor-widget-text-editor\" data-id=\"33eac66\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Table 1. Baseline characteristics.<\/b><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b0cf9b1 elementor-widget elementor-widget-image\" data-id=\"b0cf9b1\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"466\" height=\"367\" src=\"https:\/\/edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2022\/12\/Tab1111.jpg\" class=\"attachment-large size-large wp-image-7348\" alt=\"\" srcset=\"https:\/\/edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2022\/12\/Tab1111.jpg 466w, https:\/\/edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2022\/12\/Tab1111-300x236.jpg 300w\" sizes=\"(max-width: 466px) 100vw, 466px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-05e0291 elementor-widget elementor-widget-text-editor\" data-id=\"05e0291\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Perioperative outcomes<\/b><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ca35af9 elementor-widget elementor-widget-text-editor\" data-id=\"ca35af9\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>The mean cardiopulmonary bypass time was 158 \u00b1 40 min.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-499959d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"499959d\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-76c77b1\" data-id=\"76c77b1\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-8f8e7f6 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8f8e7f6\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-f2ce6a1\" data-id=\"f2ce6a1\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3f60970 elementor-widget elementor-widget-text-editor\" data-id=\"3f60970\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Five patients (5%) developed low cardiac output syndrome and two patients (2%) experienced stroke.<\/li><li>One patient died during the hospital stay (1.4%).<\/li><li>At discharge, 43 patients (49%) were free of MR, and 35 (40%) had mild and 9 (10%) moderate residual MR.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-970ef2d elementor-widget elementor-widget-text-editor\" data-id=\"970ef2d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Echocardiographic results<\/b><\/p><ul><li>At 1-year, 95.8% of patients were free of MR &gt;2+ (Kaplan-Meir analysis).<\/li><li>There was improved left ventricular (LV) geometry (remodeling) and reduced tenting parameters at 1-year.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-59f3b0b elementor-widget elementor-widget-text-editor\" data-id=\"59f3b0b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Survival<\/b><\/p><ul><li>The survival rate at 1-year was 95.5%.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3c697a5 elementor-widget elementor-widget-heading\" data-id=\"3c697a5\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Conclusion<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aec1caf elementor-widget elementor-widget-text-editor\" data-id=\"aec1caf\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Standardised subannular repair by papillary muscle repositioning showed acceptable perioperative and 1-year efficacy and safety outcomes in patients with functional MR, including a low MR &gt;2 recurrence rate.<\/p><p>Improved LV remodeling and tenting parameters were also evident 12 months after surgery.\u00a0<span style=\"font-family: MerriweatherSans;font-size: 1.14rem;font-weight: normal\">A 2-year follow-up of the study population is currently underway.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-e9885db\" data-id=\"e9885db\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-679d6a4 elementor-widget elementor-widget-heading\" data-id=\"679d6a4\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">References:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f6c574c elementor-widget elementor-widget-text-editor\" data-id=\"f6c574c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ol><li>NCT03470155. Available at: https:\/\/clinicaltrials.gov\/ct2\/show\/ NCT03470155. [Accessed September 2022].<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b26244f elementor-widget elementor-widget-text-editor\" data-id=\"b26244f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em>This document is a summary of the Girdauskas E <\/em>et al<em>. presentation, as presented at the EACTS congress and covers key information including aim, type of study, methods, results and conclusions<\/em><em>.<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-406cb63 elementor-widget elementor-widget-heading\" data-id=\"406cb63\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">The full publication is available at:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-03d1096 elementor-widget elementor-widget-text-editor\" data-id=\"03d1096\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #000000\"><strong><a style=\"color: #000000\" href=\"https:\/\/process.y-congress.com\/ScientificProcess\/data\/22\/290\/850\/693a2967-e1eb-4d2f-a526-bdc182e76d64\/Uploads\/9553_EACTS_REFORM%20MR_Abstract.pdf\">https:\/\/bit.ly\/girdauskas2022<\/a><\/strong><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a06efec elementor-widget elementor-widget-heading\" data-id=\"a06efec\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Abbreviations:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ecaf5f1 elementor-widget elementor-widget-image\" data-id=\"ecaf5f1\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"506\" height=\"205\" src=\"https:\/\/edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2022\/12\/P5.jpg\" class=\"attachment-large size-large wp-image-7428\" alt=\"\" srcset=\"https:\/\/edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2022\/12\/P5.jpg 506w, https:\/\/edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2022\/12\/P5-300x122.jpg 300w\" sizes=\"(max-width: 506px) 100vw, 506px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e2a98eb elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e2a98eb\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7eb6cb2\" data-id=\"7eb6cb2\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-92b277b elementor-widget elementor-widget-text-editor\" data-id=\"92b277b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Medical<\/strong> <strong>device<\/strong> <strong>for<\/strong> <strong>professional<\/strong> <strong>use.<\/strong> <strong>For<\/strong> <strong>a<\/strong> <strong>listing<\/strong> <strong>of<\/strong> <strong>indications,<\/strong> <strong>contraindications,<\/strong> <strong>precautions,<\/strong> <strong>warnings,<\/strong> <strong>and<\/strong> <strong>potential<\/strong><strong> adverse events, please refer to the Instructions for Use (consult eifu.edwards.com where applicable).<\/strong><\/p><p>Edwards, Edwards Lifesciences, the stylized E logo, Carpentier-McCarthy-Adams IMR ETlogix and IMR ETlogix are trademarks or service marks of Edwards Lifesciences Corporation. All other trademarks are the property of their respective owners.<\/p><p>\u00a9 2022 Edwards Lifesciences Corporation. All rights reserved. PP&#8211;EU-5310 v1.0<\/p><p><strong>Edwards<\/strong> <strong>Lifesciences<\/strong> <strong>\u2022<\/strong> Route de l\u2019Etraz 70, 1260 Nyon, Switzerland \u2022 edwards.com<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Girdauskas E, Pausch J, Eden M, Krane [&hellip;]<\/p>\n","protected":false},"author":1869,"featured_media":7934,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"tags":[],"topic_interest":[],"secondary_topic":[],"article_tags":[1224,616,1193,1164],"anatomy":[],"topics":[],"course":[],"class_list":["post-7345","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"acf":{"views":"3624","latestnews":false,"mostpopular":false,"header__style":"default","header__alternative-title":"","footer-section__show":true,"footer-section__object":false,"PathOrder":"0","slider__background-image":{"ID":7935,"id":7935,"title":"Big Size_Publications 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