{"id":10592,"date":"2023-11-02T10:39:06","date_gmt":"2023-11-02T10:39:06","guid":{"rendered":"https:\/\/edwardseducation.com\/edwardsmasters\/?p=10592"},"modified":"2023-11-14T11:52:22","modified_gmt":"2023-11-14T11:52:22","slug":"one-year-clinical-outcomes-following-edwards-inspiris-resilia-aortic-valve-implantation-in-487-young-patients-with-severe-aortic-stenosis-a-single-centre-experience","status":"publish","type":"post","link":"https:\/\/edwardseducation.com\/edwardsmasters\/one-year-clinical-outcomes-following-edwards-inspiris-resilia-aortic-valve-implantation-in-487-young-patients-with-severe-aortic-stenosis-a-single-centre-experience\/","title":{"rendered":"One-year clinical outcomes following Edwards INSPIRIS RESILIA aortic valve implantation in 487 young patients with severe aortic stenosis: A single-centre experience"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"10592\" class=\"elementor elementor-10592\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0d42439 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0d42439\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-61e45d1\" data-id=\"61e45d1\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a54d9ba elementor-widget elementor-widget-text-editor\" data-id=\"a54d9ba\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Porto A, Stolpe G, Badaoui R <em>et al.<\/em><\/p><p><em>Frontiers in Cardiovascular Medicine. <\/em>2023; doi:10.3389\/fcvm.2023.1196447.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b10178e elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b10178e\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-fd192ea\" data-id=\"fd192ea\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0f9b7ff elementor-widget elementor-widget-heading\" data-id=\"0f9b7ff\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Key points:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cb508a7 elementor-widget elementor-widget-text-editor\" data-id=\"cb508a7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>The management of aortic stenosis in young patients is an important topic.<\/li><li>The INSPIRIS RESILIA valve demonstrated encouraging survival, clinical and haemodynamic outcomes at 1-year follow-up in a large, single-center prospective study of consecutive young patients with severe aortic stenosis (AS).<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-612a868 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"612a868\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-02688af\" data-id=\"02688af\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-108bfb4 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"108bfb4\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-40d922a\" data-id=\"40d922a\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b37d9c8 elementor-widget elementor-widget-heading\" data-id=\"b37d9c8\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Background information<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-82583c7 elementor-widget elementor-widget-text-editor\" data-id=\"82583c7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul>\n \t<li>Aortic bioprostheses are increasingly being used in younger patients with severe AS, despite the risk of accelerated structural valve deterioration (SVD) and subsequent need for reintervention, especially in patients under 65 years of age.<\/li>\n \t<li>The INSPIRIS RESILIA valve, a bovine pericardial tissue valve with a special integrity preservation technology, represents a promising solution to SVD.<\/li>\n \t<li>Early clinical experience with the INSPIRIS RESILIA valve has shown encouraging results in terms of early safety and efficacy of aortic valve replacement (AVR).<\/li>\n \t<li>Intermediate-term outcomes have shown the absence of early thrombosis events and non-calcific valve deterioration.<sup>1-2<\/sup><\/li>\n<\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-967a354 elementor-widget elementor-widget-heading\" data-id=\"967a354\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Aim<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-efc213f elementor-widget elementor-widget-text-editor\" data-id=\"efc213f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>To evaluate the 1-year outcomes of the INSPIRIS RESILIA aortic valve in a population of young patients who underwent AVR for severe AS.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4370127 elementor-widget elementor-widget-heading\" data-id=\"4370127\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Type of study<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-71caffb elementor-widget elementor-widget-text-editor\" data-id=\"71caffb\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>A prospective single-centre study.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6e3428b elementor-widget elementor-widget-heading\" data-id=\"6e3428b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Results<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d4ed039 elementor-widget elementor-widget-text-editor\" data-id=\"d4ed039\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Baseline and procedural characteristics<\/b><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-254a907 elementor-widget elementor-widget-text-editor\" data-id=\"254a907\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Mean (\u00b1 standard deviation [SD]) age was 58.2 \u00b1 11.5 years and 75.2% were male.<\/li><li>Most of the interventions were elective (endocarditis 18.7%; 14.5% redo surgery; and 31.2% AS without aortic regurgitation), with a mean (\u00b1 SD) EuroSCORE II of 4.8 \u00b1 7.9%.<\/li><li>Patients 50 years of age or younger had a higher EuroSCORE II (5.3 \u00b1 9.6%) and were more likely to present with preoperative IE (29.2% vs 18.5% for the 50&lt;65 group and 12.5% for the \u226565 group).<\/li><li>210 patients (43.1%) had a concomitant procedure performed perioperatively:<br \/>\u2013 23.4% had aortic replacement.<br \/>\u2013 9.2% had mitral valve surgery replacement or repair.<br \/>\u2013 7.4% had coronary artery bypass graft.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-254d744 elementor-widget elementor-widget-text-editor\" data-id=\"254d744\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Clinical outcomes at 1 year<\/b><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-88ed69d elementor-widget elementor-widget-text-editor\" data-id=\"88ed69d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>The Kaplan\u2013Meier estimated survival rate was 96.4%.<\/li><li>There was no significant difference in either overall or cardiac mortality, or major cardiac events between the three age groups (Table 1).<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-daa63f4\" data-id=\"daa63f4\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-52aec63 elementor-widget elementor-widget-heading\" data-id=\"52aec63\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Endpoints<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d11654e elementor-widget elementor-widget-text-editor\" data-id=\"d11654e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>The primary endpoint was overall mortality at 1 year.<\/li><li>Secondary endpoints included:<br \/>\u2013 Cardiovascular mortality.<br \/>\u2013 Major adverse cardiac events (defined by rehospitalisation for congestive heart failure, stroke or myocardial infarction).<br \/>\u2013 Evolution of New York Heart Association (NYHA) functional status.<br \/>\u2013 Haemodynamic follow- up.<br \/>\u2013 Mortality and morbidity of infective endocarditis (IE).<\/li><\/ul><ul><li>All outcomes were defined according to the Valve Academic Research Consortium-2 consensus document.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f298094 elementor-widget elementor-widget-heading\" data-id=\"f298094\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Methods<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-feeda67 elementor-widget elementor-widget-text-editor\" data-id=\"feeda67\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>A total of 487 consecutive patients with severe AS who received the INSPIRIS RESILIA valve between June 2017 and July 2021 at La Timone Hospital in Marseille, France, were included in the study.<\/li><li>Clinical assessment and transthoracic echocardiography were performed preoperatively and at 1 year postoperatively.<\/li><li>Subgroup analyses were conducted based on age (\u226450 years, 50&lt;65 years and \u226565 years) and preoperative IE status.\u00a0<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-efd0dc0 elementor-widget elementor-widget-text-editor\" data-id=\"efd0dc0\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Figure 1: Change in NYHA class from baseline to 1-year follow-up in patients treated with the INSPIRIS RESILIA valve<\/b><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4f248f6 elementor-widget elementor-widget-image\" data-id=\"4f248f6\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"426\" height=\"305\" src=\"https:\/\/edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2023\/11\/portotab1.png\" class=\"attachment-large size-large wp-image-10594\" alt=\"\" srcset=\"https:\/\/edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2023\/11\/portotab1.png 426w, https:\/\/edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2023\/11\/portotab1-300x215.png 300w\" sizes=\"(max-width: 426px) 100vw, 426px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1b56561 elementor-widget elementor-widget-text-editor\" data-id=\"1b56561\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Functional status was significantly improved (p&lt;0.0001) (Figure 1).<\/li><li>Severe patient\u2013prosthesis mismatch and severe intravalvular regurgitation occurred in 1.2% and 0.6% of patients, respectively.\u00a0<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-65cba45 elementor-widget elementor-widget-text-editor\" data-id=\"65cba45\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Haemodynamic properties<\/b><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-20f0954 elementor-widget elementor-widget-text-editor\" data-id=\"20f0954\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Haemodynamic performance was significantly improved (baseline vs 1-year postoperative data; median [interquartile range]; p&lt;0.001 for all):<br \/>\u2013 Aortic valve area index: 0.4 (0.4, 0.5)<em> versus<\/em> 1.0 (0.8, 1.3).<br \/>\u2013 Mean gradient: 49 mmHg (43, 55) <em>versus<\/em> 9 mmHg (7, 12).<br \/>\u2013 Peak velocity: 4.4 m\/s (4.0, 4.9) <em>versus<\/em> 2.1 m\/s (1.8, 2.4).<\/li><li>There were no significant differences in these parameters between the age groups.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2fe217f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2fe217f\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-fe33f81\" data-id=\"fe33f81\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f804c2d elementor-widget elementor-widget-text-editor\" data-id=\"f804c2d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Table 1: Mortality and morbidity outcomes at 1 year among patients treated with the INSPIRIS RESILIA valve<\/b><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7517e84 elementor-widget elementor-widget-image\" data-id=\"7517e84\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"839\" height=\"426\" src=\"https:\/\/edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2023\/11\/mortality-and-morbidity.png\" class=\"attachment-large size-large wp-image-10650\" alt=\"\" srcset=\"https:\/\/edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2023\/11\/mortality-and-morbidity.png 839w, https:\/\/edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2023\/11\/mortality-and-morbidity-300x152.png 300w, https:\/\/edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2023\/11\/mortality-and-morbidity-768x390.png 768w\" sizes=\"(max-width: 839px) 100vw, 839px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-af2de1a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"af2de1a\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1b333f9\" data-id=\"1b333f9\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-f7fbc68 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f7fbc68\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-2419319\" data-id=\"2419319\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ea76e73 elementor-widget elementor-widget-text-editor\" data-id=\"ea76e73\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Infective endocarditis<\/b><br><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-583ab26 elementor-widget elementor-widget-text-editor\" data-id=\"583ab26\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>The Kaplan\u2013Meier estimated survival rates at 1 year were 97.9% for the IE-free group and 89.5% for the IE group.<\/li><li>Excluding IE-related causes, no SVD and valve failure requiring redo surgery were reported.\u00a0<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-91a8f10 elementor-widget elementor-widget-heading\" data-id=\"91a8f10\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Limitations<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-98a7e6a elementor-widget elementor-widget-text-editor\" data-id=\"98a7e6a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>This was a single-arm study without comparative groups.<\/li><li>Patients were only followed up for 1 year; therefore, long-term durability cannot be fully assessed.<\/li><li>There was a high prevalence of preoperative IE in patients 50 years and younger, which explains the high rate of adverse events in this cohort.<br \/>\u2013 While the data seem to favour the INSPIRIS RESILIA valve in this population, the number of patients is too low to draw any conclusions.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-47719a9 elementor-widget elementor-widget-heading\" data-id=\"47719a9\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Conclusions<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-428a193 elementor-widget elementor-widget-text-editor\" data-id=\"428a193\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>The INSPIRIS RESILIA valve provides encouraging clinical outcomes with excellent 1-year survival rates and good haemodynamic performance.<\/li><li>Further studies are needed to assess long-term valve durability.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-fd3f0b1\" data-id=\"fd3f0b1\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0b782b4 elementor-widget elementor-widget-heading\" data-id=\"0b782b4\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">References<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e3da7f0 elementor-widget elementor-widget-text-editor\" data-id=\"e3da7f0\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ol><li>Bartu\u015b K, Litwinowicz R, Ku\u015bmierczyk M <em>et al.<\/em> Primary safety and effectiveness feasibility study after surgical aortic valve replacement with a new generation bioprosthesis: One-year outcomes. <br \/><em>Kardiol Pol.<\/em> 2018; <strong>76:<\/strong> 618\u201324.<\/li><li>Johnston DR, Griffith BP, Puskas JD et al. Intermediate-term outcomes of aortic valve replacement using a bioprosthesis with a novel tissue. <em>J Thorac Cardiovasc Surg.<\/em> 2021; <strong>162:<\/strong> 1478\u201385.<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d61dec9 elementor-widget elementor-widget-text-editor\" data-id=\"d61dec9\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em>This document is a summary of the Porto A et al. paper<\/em><br \/><em>and covers key information including aim, type of study,<\/em><br \/><em>methods, results and conclusions<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0f33b55 elementor-widget elementor-widget-text-editor\" data-id=\"0f33b55\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>The abstract is available at:<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-743b0c4 elementor-widget elementor-widget-text-editor\" data-id=\"743b0c4\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2023.1196447\/abstract\"><strong>doi: 10.3389\/fcvm.2023.1196447<\/strong><\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-98fb997 elementor-widget elementor-widget-heading\" data-id=\"98fb997\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Abbreviations<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f26e8e5 elementor-widget elementor-widget-image\" data-id=\"f26e8e5\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"459\" height=\"195\" src=\"https:\/\/edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2023\/11\/abbrportoetal.png\" class=\"attachment-large size-large wp-image-10599\" alt=\"\" srcset=\"https:\/\/edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2023\/11\/abbrportoetal.png 459w, https:\/\/edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2023\/11\/abbrportoetal-300x127.png 300w\" sizes=\"(max-width: 459px) 100vw, 459px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6a0a560 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6a0a560\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-46de8ff\" data-id=\"46de8ff\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2b9d291 elementor-widget elementor-widget-text-editor\" data-id=\"2b9d291\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>No clinical data are available that evaluate the long-term impact of RESILIA tissue in patients.<\/strong><\/p><p><strong>Medical<\/strong> <strong>device<\/strong> <strong>for<\/strong> <strong>professional<\/strong> <strong>use.<\/strong> <strong>For<\/strong> <strong>a<\/strong> <strong>listing<\/strong> <strong>of<\/strong> <strong>indications,<\/strong> <strong>contraindications,<\/strong> <strong>precautions,<\/strong> <strong>warnings,<\/strong> <strong>and<\/strong> <strong>potential<\/strong><strong> adverse events, please refer to the Instructions for Use (consult eifu.edwards.com where applicable).<\/strong><\/p><p>Edwards, Edwards Lifesciences, the stylized E logo, Carpentier-Edwards, Carpentier-Edwards PERIMOUNT, Carpentier-Edwards PERIMOUNT Magna Ease, EDWARDS INTUITY, EDWARDS INTUITY Elite, INSPIRIS, INSPIRIS RESILIA, Magna, Magna Ease, PERI,<\/p><p>PERIMOUNT, PERIMOUNT Magna and RESILIA are trademarks or service marks of Edwards Lifesciences Corporation. All other trademarks are the property of their respective owners.<\/p><p>\u00a9 2023 Edwards Lifesciences Corporation. All rights reserved. PP&#8211;EU-6744 v1.0<\/p><p><strong>Edwards<\/strong> <strong>Lifesciences<\/strong> <strong>\u2022<\/strong> Route de l\u2019Etraz 70, 1260 Nyon, Switzerland \u2022 edwards.com<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Porto A, Stolpe G, Badaoui R et [&hellip;]<\/p>\n","protected":false},"author":1502,"featured_media":10744,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"tags":[],"topic_interest":[],"secondary_topic":[],"article_tags":[],"anatomy":[],"topics":[],"course":[],"class_list":["post-10592","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"acf":{"MobileLandscapeImage":{"ID":10745,"id":10745,"title":"Publication summary - Porto et al 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