{"id":10508,"date":"2023-11-02T10:34:20","date_gmt":"2023-11-02T10:34:20","guid":{"rendered":"https:\/\/edwardseducation.com\/edwardsmasters\/?p=10508"},"modified":"2023-11-02T11:20:55","modified_gmt":"2023-11-02T11:20:55","slug":"durability-of-bioprosthetic-aortic-valve-replacement-in-patients-under-the-age-of-60-years-1-year-follow-up-from-the-prospective-indure-registry","status":"publish","type":"post","link":"https:\/\/edwardseducation.com\/edwardsmasters\/durability-of-bioprosthetic-aortic-valve-replacement-in-patients-under-the-age-of-60-years-1-year-follow-up-from-the-prospective-indure-registry\/","title":{"rendered":"Durability of bioprosthetic aortic valve replacement in patients under the age of 60 years \u2013 1-year follow-up from the prospective INDURE registry"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"10508\" class=\"elementor elementor-10508\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-43a8f17 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"43a8f17\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-bbb45c1\" data-id=\"bbb45c1\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-68bd3ab elementor-widget elementor-widget-text-editor\" data-id=\"68bd3ab\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Meuris B, Roussel JC, Borger MA <em>et al.<\/em><\/p><p><em>Interdisciplinary CardioVascular and Thoracic Surgery.<\/em> 2023; doi:10.1093\/icvts.ivad115.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-37c207a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"37c207a\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-780d784\" data-id=\"780d784\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0d2f164 elementor-widget elementor-widget-heading\" data-id=\"0d2f164\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Key points:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ece3a33 elementor-widget elementor-widget-text-editor\" data-id=\"ece3a33\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>The 1-year data from the INSPIRIS RESILIA Durability Registry (INDURE) demonstrate good safety outcomes with surgical aortic valve replacement (SAVR) in young patients characterised by a high rate of bicuspid aortic valve (BAV) and aortic regurgitation; survival rates at 1 year were better than predicted and quality of life (QoL) was fully restored within 3\u20136 months.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f3f3155 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f3f3155\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3630dce2\" data-id=\"3630dce2\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-2a0165cd elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2a0165cd\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-63a8b59a\" data-id=\"63a8b59a\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5a24724b elementor-widget elementor-widget-heading\" data-id=\"5a24724b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Background information<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-20151a12 elementor-widget elementor-widget-text-editor\" data-id=\"20151a12\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul>\n \t<li>Bioprosthetic valves have gained popularity in younger patients due to their durability, decreased reoperation risk and the possibility of transcatheter valve-in-valve procedures, as supported by retrospective studies and current guidelines.<sup>1<\/sup><\/li>\n \t<li>The INSPIRIS RESILIA aortic valve, made of bovine pericardial tissue, has shown promising haemodynamic and anticalcification properties in preclinical and clinical studies, including excellent safety and effectiveness at 5 years.<sup>2\u20138<\/sup> However, data specifically focusing on patients under 60 years of age are limited.<\/li>\n<\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-390a91a elementor-widget elementor-widget-heading\" data-id=\"390a91a\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Aim<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7436d239 elementor-widget elementor-widget-text-editor\" data-id=\"7436d239\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>To assess 1-year safety and clinical outcomes in patients under 60 years of age undergoing SAVR with the INSPIRIS RESILIA aortic valve.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-17e89995 elementor-widget elementor-widget-heading\" data-id=\"17e89995\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Type of study<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-277982a4 elementor-widget elementor-widget-text-editor\" data-id=\"277982a4\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>A prospective, open-label, multicentre international registry with centres across Europe and Canada.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2731e3bb elementor-widget elementor-widget-heading\" data-id=\"2731e3bb\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Endpoints<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-265e1fcb elementor-widget elementor-widget-text-editor\" data-id=\"265e1fcb\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Primary endpoint: <br \/>\u2013 Time-related valve safety at 1 year: freedom from specific events according to Valve Academic Research Consortium (VARC)-2 criteria, including repeat procedure, prosthetic valve endocarditis, prosthetic valve thrombosis, thromboembolic events (e.g. stroke) and life-threatening bleeding.<\/li><li>Secondary endpoints:<p>\u2013Haemodynamic performance assessment.<\/p><p>\u2013 Durability evaluation of INSPIRIS RESILIA aortic valve (composite endpoint of time-related valve safety [VARC-2; adjudicated by an independent clinical events committee] and structural valve deterioration [SVD] stage 3 [VARC-3; based on a standardised Core Lab adjudicated assessment]).<\/p><p>\u2013 Clinical outcomes: all cause, cardiovascular and valve-related mortality; valve-related dysfunction; need for repeat procedures; permanent pacemaker implantation; acute kidney injury stage 2 or 3; and New York Heart Association (NYHA) functional class.<\/p><p>\u2013 Evaluation of QoL using Kansas City Cardiomyopathy Questionnaire (KCCQ) and Short Form-12 Health Survey (SF-12v2).<\/p><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-16f96c2\" data-id=\"16f96c2\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7cedd21e elementor-widget elementor-widget-heading\" data-id=\"7cedd21e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Methods<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-548b7971 elementor-widget elementor-widget-text-editor\" data-id=\"548b7971\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>\u00a0421 patients who underwent SAVR with the INSPIRIS RESILIA aortic valve at 21 sites across nine countries were included.<\/li><li>Inclusion criteria included planned native valve replacement based on preoperative evaluation.<\/li><li>Exclusion criteria included inability to implant valve per device Instructions for Use, active endocarditis\/myocarditis within last 3 months, previous aortic valve\u00a0 replacement, Bentall procedure or surgery on other valves, and life expectancy of less than 12 months.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7b59af4 elementor-widget elementor-widget-heading\" data-id=\"7b59af4\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Results<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-daf61ec elementor-widget elementor-widget-text-editor\" data-id=\"daf61ec\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Baseline and procedural characteristic<\/strong><br \/>\u2022 Common comorbidities included arterial hypertension, coronary artery disease and type II diabetes.<br \/><strong>Table 1: Patient baseline and procedural <\/strong><strong>characteristics<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-beb04ff elementor-widget elementor-widget-image\" data-id=\"beb04ff\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"390\" height=\"440\" src=\"https:\/\/edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2023\/11\/firsttable.png\" class=\"attachment-large size-large wp-image-10537\" alt=\"\" srcset=\"https:\/\/edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2023\/11\/firsttable.png 390w, https:\/\/edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2023\/11\/firsttable-266x300.png 266w\" sizes=\"(max-width: 390px) 100vw, 390px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7c58f7a elementor-widget elementor-widget-text-editor\" data-id=\"7c58f7a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Early (30 days) and 1-year outcomes<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a13f659 elementor-widget elementor-widget-text-editor\" data-id=\"a13f659\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>At 30 days, 3 patients (0.7%) died due to cardiovascular causes. No valve-related mortality was reported in the 1-year follow-up.<\/li><li>\u00a0Valve-related safety events occurred in 25 patients (5.9%) within 30 days and in 9 patients (2.2% per valve-years) from 30 days to 1 year.<\/li><li>\u00a0Within 1 year, 7 patients (1.7%) died, with 5 deaths related to cardiovascular causes. No patients had SVD stage 3 (VARC-3).<\/li><li>Severe patient\u2013prosthesis mismatch was observed in 1.0% of patients.<\/li><li>The majority of patients showed improvement in NYHA functional class, with 81.8% in class I and only 3.6% in class III\/IV at 1 year, compared with 21.9% and 27.2% at baseline.<\/li><li>No cases of prosthetic valve leakage were reported.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-53460943 elementor-widget elementor-widget-text-editor\" data-id=\"53460943\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Quality-of-life outcomes<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5043111a elementor-widget elementor-widget-text-editor\" data-id=\"5043111a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>SF-12v2 physical summary score showed improvements at 3\u20136 months and 1 year compared with baseline (Table 2). Patients returned to the expected QoL of the general population, achieving a mean score of 50 points within 3\u20136 months.<\/li><li>\u00a0KCCQ total symptom score and clinical summary score increased at 3\u20136 months and 1 year, with a notable increase in overall summary score at 1 year (Table 2). Patients scored 75\u2013100 points (= good to excellent health status) within 3\u20136 months.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ab5f9b6 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ab5f9b6\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6946ff8\" data-id=\"6946ff8\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ce241c6 elementor-widget elementor-widget-text-editor\" data-id=\"ce241c6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Table 2: Quality of life outcomes at baseline, 3\u20136 months and 1 year<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ee3c1b1 elementor-widget elementor-widget-image\" data-id=\"ee3c1b1\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"819\" height=\"350\" src=\"https:\/\/edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2023\/11\/secondtable.png\" class=\"attachment-large size-large wp-image-10544\" alt=\"\" srcset=\"https:\/\/edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2023\/11\/secondtable.png 819w, https:\/\/edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2023\/11\/secondtable-300x128.png 300w, https:\/\/edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2023\/11\/secondtable-768x328.png 768w\" sizes=\"(max-width: 819px) 100vw, 819px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1205a81 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1205a81\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-9108181\" data-id=\"9108181\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-261c4e9 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"261c4e9\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-9525324\" data-id=\"9525324\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b282d20 elementor-widget elementor-widget-heading\" data-id=\"b282d20\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Limitations<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c3168fc elementor-widget elementor-widget-text-editor\" data-id=\"c3168fc\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>\u00a0The study did not include an active control group, so comparisons between different bioprosthetic valves could not be made and selection bias cannot be excluded. Furthermore, there was no comparison with the outcomes and performance of mechanical valves.<\/li><li>These results are based on 1-year data, so may not reflect long-term safety outcomes, although the cohort will be followed for 5 years.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-828733e elementor-widget elementor-widget-heading\" data-id=\"828733e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Conclusions<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aaec21d elementor-widget elementor-widget-text-editor\" data-id=\"aaec21d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>\u00a0The results of this study demonstrate good outcomes in terms of safety, early improvement in QoL and high survival rates at 1 year for patients under the age of 60 who received the INSPIRIS RESILIA valve.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3dc5622 elementor-widget elementor-widget-heading\" data-id=\"3dc5622\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">References<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c65a64a elementor-widget elementor-widget-text-editor\" data-id=\"c65a64a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ol><li>\u00a0Christ T, Grubitzsch H, Claus B <em>et al.<\/em> Stentless aortic valve replacement in the young patient: Long-term results. <em>J Cardiothorac Surg.<\/em> 2013; 8: 68.<\/li><li>\u00a0Flameng W, Hermans H, Verbeken E <em>et al.<\/em> A randomized assessment of an advanced tissue preservation technology in the juvenile sheep model.<em> J Thorac Cardiovasc Surg.<\/em> 2015; 149: 340\u20135.<\/li><li>\u00a0Puskas JD, Bavaria JE, Svensson LG<em> et al.<\/em> The COMMENCE trial: 2-year outcomes with an aortic bioprosthesis with RESILIA tissue. <em>Eur J Cardiothorac Surg.<\/em> 2017; <strong>52:<\/strong> 432\u20139.<\/li><li>\u00a0Bartus K, Litwinowicz R, Kusmierczyk M <em>et al.<\/em> Primary safety and effectiveness feasibility study after surgical aortic valve replacement with a new generation bioprosthesis: One-year outcomes. <em>Kardiol Pol.<\/em> 2018; <strong>76<\/strong>: 618\u201324.<\/li><li><p>\u00a0Bartus K, Litwinowicz R,\u00a0 \u00a0 \u00a0 \u00a0Bilewska A<em> et al.<\/em> Intermediate\u00a0 term outcomes after aortic\u00a0 valve replacement with a novel\u00a0 RESILIA\u2122 tissue\u00a0 bioprosthesis. <em>J Thorac Dis.\u00a0<\/em> 2019; 11: 3039\u201346.<\/p><\/li><li><p>\u00a0Useini D, Schlomicher M,\u00a0 Haldenwang P <em>et al.<\/em> Early\u00a0 results after aortic valve\u00a0 replacement using last\u00a0 generation bioprosthetic aortic\u00a0 valve. <em>Heart Surg Forum.<\/em> 2021; 24: E598\u2013962.<\/p><\/li><li><p>Bavaria JE, Griffith B,\u00a0 Heimansohn DA <em>et al.<\/em> Five\u00a0 year outcomes of the COMMENCE trial investigating aortic valve\u00a0 replacement with RESILIA\u00a0 tissue. <em>Ann Thorac Surg.<\/em> 2022; 115: 1429\u201336.<\/p><\/li><li><p>\u00a0Fukunaga N, Yoshida S,\u00a0 Shimoji A <em>et al.<\/em> Hemodynamic\u00a0 performance of INSPIRIS\u00a0 RESILIA aortic bioprosthesis for severe aortic stenosis: 2\u00a0 year follow-up in Japanese\u00a0 cohort. <em>J Artif Organs<\/em>. 2022; <strong>25:<\/strong> 323\u20138.<\/p><p><em>This document is a summary of the Meuris B et al. paper<\/em><br \/><em>and covers key information including aim, type of study,<\/em><br \/><em>methods, results and conclusion.<\/em><\/p><\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-95460fe\" data-id=\"95460fe\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0b16efd elementor-widget elementor-widget-heading\" data-id=\"0b16efd\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">The full publication is available at:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-41173e7 elementor-widget elementor-widget-text-editor\" data-id=\"41173e7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em><a href=\"https:\/\/academic.oup.com\/icvts\/article\/37\/4\/ivad115\/7225860?login=false\"><b>doi.org\/10.1093\/icvts\/ivad115<\/b><\/a><\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b26fd98 elementor-widget elementor-widget-heading\" data-id=\"b26fd98\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Abbreviations<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a3c6f31 elementor-widget elementor-widget-image\" data-id=\"a3c6f31\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"330\" height=\"221\" src=\"https:\/\/edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2023\/11\/BAV.png\" class=\"attachment-large size-large wp-image-10579\" alt=\"\" srcset=\"https:\/\/edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2023\/11\/BAV.png 330w, https:\/\/edwardseducation.com\/edwardsmasters\/wp-content\/uploads\/sites\/2\/2023\/11\/BAV-300x201.png 300w\" sizes=\"(max-width: 330px) 100vw, 330px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0cfad85 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0cfad85\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-33fb83f\" data-id=\"33fb83f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-10dd9ee elementor-widget elementor-widget-text-editor\" data-id=\"10dd9ee\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>No clinical data are available that evaluate the long-term impact of RESILIA tissue in patients.<\/strong><br \/><strong><br \/>Medical device for professional use. For a listing of indications, contraindications, precautions, warnings, and potential<\/strong><br \/><strong>adverse events, please refer to the Instructions for Use (consult eifu.edwards.com where applicable).<\/strong><br \/><br \/>Refer to device instructions for use for important warnings related to VFit technology. These features have not been observed in clinical studies to establish the safety and effectiveness of the model 11500A for use in valve-in valve procedures. VFit technology is available on sizes 19\u201325 mm.<br \/>Edwards, Edwards Lifesciences, the stylized E logo, COMMENCE, NSPIRIS,\u00a0 RESILIA, RESILIA and VFit are trademarks or service marks of Edwards Lifesciences Corporation. All other trademarks are the property of their respective owners<\/p><p>\u00a9 2023 Edwards Lifesciences Corporation. All rights reserved. PP&#8211;EU-6745 v1.0<\/p><p><strong>Edwards<\/strong> <strong>Lifesciences<\/strong> <strong>\u2022<\/strong> Route de l\u2019Etraz 70, 1260 Nyon, Switzerland \u2022 edwards.com<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Meuris B, Roussel JC, Borger MA et [&hellip;]<\/p>\n","protected":false},"author":1502,"featured_media":10611,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"tags":[],"topic_interest":[],"secondary_topic":[],"article_tags":[],"anatomy":[],"topics":[],"course":[],"class_list":["post-10508","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"acf":{"MobileLandscapeImage":{"ID":10612,"id":10612,"title":"Publication summary - Meuris et al 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