Colder temperatures mitigate cognitive decline after cardiovascular surgery
March 23, 2017
Deep hypothermia is better than high-moderate hypothermia at protecting the brain after circulatory arrest for aortic arch surgery, report researchers at Duke University Medical Centre, Durham, US.
Rebecca Klinger and colleagues studied 34 patients who underwent hypothermic circulatory arrest for elective proximal aortic reconstructive surgery with concomitant proximal (hemi-) arch replacement. The patients were divided into three groups: low-moderate hypothermia (cooled to 20.1–24.0°C), high-moderate hypothermia (cooled to 24.1–28.0°C) and deep hypothermia (cooled to less than 20°C).
Patients in the high‑moderate hypothermia group had poorer neurocognitive scores at follow-up than those in the low-moderate and deep hypothermia groups. The researchers also found significant differences in grey matter in the right parahippocampal, mesial frontal and posterior cingulate cortices between the high-moderate and deep hypothermia groups. These differences were associated with short-term memory decline in the high-moderate hypothermia group.
Link to abstract: